VNARS: AN ANCIENT AND UNIQUE REPERTOIRE OF MOLECULES THAT DELIVER SMALL, SOLUBLE, STABLE AND HIGH AFFINITY BINDERS OF PROTEINS

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins

At 420 million years, the variable domain of New Antigen Receptors or VNARs are undoubtedly the oldest (and smallest) antigen binding single domains identified in the vertebrate kingdom.Their role as an integral part of the adaptive immune system of sharks has been well established and has served to provide a greater understanding of the evolution

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Long term outcomes of open reduction internal fixation versus external fixation of distal radius fractures: A meta-analysis

Distal radius fractures are among the most common fractures encountered in the clinical setting.Of these common fractures, it has been said that up to 60% are intraarticular in nature.Intra-articular or unstable and comminuted fractures represent severe and high energy injuries.Despite a large amount of literature, it is surgeon preference which de

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